INTEGRALL

The Integron Database

Glossary


A

Gene aacA (synonym aac(6'))
Product aminoglycoside 6'-N-acetyltransferase
Function confers resistance to amikacin, dibekacin, isepamicin, netilmicin, sisomicin and tobramycin
 
 
Gene aacC (synonym aac(3'))
Product aminoglycoside 3'-N-acetyltransferase
Function confers resistance to aminoglycosides such as dibekacin, gentamicin, kanamycin, lividomycin, neomycin, paromomycin, sisomicin and tobramycin
 
Gene aadA (synonym ant(3'))
Product aminoglycoside 3'-adenyltransferase
Function confers resistance to streptomycin and spectinomycin
 
Gene aadB (synonym ant(2'))
Product aminoglycoside 2’-adenyltransferase
Function confers resistance to kanamycin, gentamicin, tobramycin, dibekacin and sisomicin
 
Gene abc MDR
Product multi-drug resistance
Function ABC MDR transporter
 
Gene acp
Product acyl-carrier protein
Function acyl-carrier protein
 
Gene ampR
Product lysR-type transcriptional regulator
Function
 
Gene aphA
Product aminoglycoside 3'-phosphotransferase
Function confers resistance to gentamincin, kanamycin, lividomycin, neomycin, paromomycin and ribostamycin
 
Gene appA
Product oligopeptide ABC transporter
Function transport of branched chain amino acids
 
Gene arr
Product ADP-ribosyl transferase
Function confers resistance to rifampicin
 

B

Gene blaAmpC
Product class C beta-lactamase AMPC
Function confers resistance to beta-lactams like oxyimino-beta-lactams and to cephamycins
 
Gene blaBEL
Product extended-spectrum class A beta-lactamase
Function confers resistance to beta-lactams including most expanded-spectrum cephalosporins and aztreonam
 
Gene blaCEF
Product class A beta-lactamase CEF
Function confers resistance to beta-lactams like ceftazidime
 
Gene blaCTX-M
Product class A beta-lactamase CTX-M
Function confers resistance to beta-lactam antibiotics like penicillins, cephalosporins, cephamycins, ertapenems and carbapenems; displays higher activities against the cephalosporin cefotaxime.
 
Gene blaDHA
Product plasmid encoded class C beta-lactamase
Function confers resistance to beta-lactam antibiotics
 
Gene blaESP
Product extended-spectrum beta-lactamase
Function confers resistance to beta-lactam antibiotics
 
Gene blaGES
Product extended-spectrum class A beta-lactamase
Function confers resistance to beta-lactam antibiotics like expanded-spectrum cephalosporins (e.g. ceftriaxone, cefotaxime,and ceftazidime), aztreonam and related oxyimino-beta-lactams
 
Gene blaIBC (synonym blaGES-7/-8)
Product extended spectrum beta-lactamase
Function confers resistance to beta-lactam antibiotics like expanded-spectrum cephalosporins (e.g. ceftriaxone, cefotaxime,and ceftazidime), aztreonam and related oxyimino-beta-lactams.
 
Gene blaIMP
Product class B beta-lactamase (metallo-beta-lactamase)
Function confers resistance to beta-lactam antibiotics except monobactams
 
Gene blaOXA
Product class D beta-lactamase (oxacillinase)
Function confers resistance to beta-lactam antibiotics like ampicillin, cephalothin, oxacillin and cloxacillin
 
Gene blaP1
Product PSE-1/CARB-2 beta-lactamase
Function confers resistance to beta-lactam antibiotics including carbenicillin
 
Gene blaSHV
Product class A beta-lactamase
Function confers resistance to beta-lactam antibiotics
 
Gene blaVEB
Product extended-spectrum class A beta-lactamase
Function confers resistance to beta-lactam antibiotics like expanded-spectrum cephalosporins (e.g. ceftriaxone, cefotaxime,and ceftazidime), aztreonam and related oxyimino-beta-lactams
 
Gene blaVIM
Product class B beta-lactamase (metallo-beta-lactamase)
Function confers resistance to beta-lactam antibiotics except monobactams
 
Gene blaTEM
Product class A beta-lactamase
Function confers resistance to penicillins and cephalosporins
 
Gene blaTLA
Product extended-spectrum class A beta-lactamase
Function confers resistance to beta-lactams including cefotaxime, ceftazidime and aztreonam
 

C

Gene cml
Product chloramphenicol acetyltransferase
Function confers resistance to chloramphenicol
 
Gene catB
Product chloramphenicol acetyltransferase
Function confers resistance to chloramphenicol
 
Gene chrA
Product chromate ion transport protein
Function involved in chromate ion transport
 
Gene cel
Product cellulase
Function
 

D

Gene dfr (synonym dhfr)
Product dihydrofolate reductase
Function confers resistance to trimethoprim

E

 
Gene ereA
Product erythromycin esterase
Function confers resistance to erythromycin
 
Gene estX
Product putative esterase
Function
 
Gene ectr
Product maturase-related protein
Function
 
Gene elip
Product putative esterase
Function
 

F

Gene folA
Product dihydrofolate reductase type I
Function confers resistance to trimethoprim
 
Gene flo
Product chloramphenicol/florfenicol exporter
Function confers resistance to chloramphenicol and florfenicol
 

G

Gene groEL
Product GroEL
Function chaperone; heat shock protein
 

I

Gene ins
Product putative transposase
Function
 
Gene intI
Product integron integrase
Function catalyses insertion and excision of gene cassettes
 

L

Gene linF
Product LinF protein
Function involved in resistance to lincosamides
 
Gene lip
Product triacylglycerol acyl hydrolase
Function
 
Gene lnuF
Product lincosamide nucleotidyltransferase
Function confers resistance to lincosamides
 

Q

Gene qac
Product quaternary ammonium compound resistance protein
Function confers resistance to quaternary ammonium compounds
 
Gene qepA
Product quinolone efflux pump
Function confers resistance to quinolones
 
Gene qnr
Product fluoroquinolone resistance protein
Function confers resistance to fluoroquinolones
 

P

Gene pigH
Product xanthomonadin biosynthesis-related protein
Function
 
Gene psp
Product phosphoserine phosphatase
Function
 

R

Gene rcr3 (synonym orf2)
Product probable rolling circle replication initiation protein
Function responsible for the movement of CR3
 
Gene rmtB
Product 16S rRNA methylase
Function

S

Gene sap
Product peptide transport system permease
Function
 
Gene sat
Product streptothricin acetyltransferase
Function confers resistance to streptothricin
 
Gene smr
Product small multidrug resistance protein
Function
 
Gene smtr
Product maturase-related protein
Function
 
Gene str
Product streptomycin resistance protein
Function confers resistance to streptomycin
 
Gene sul
Product sulphonamide resistant dihydropteroate synthase
Function confers resistance to sulphonamides
 

T

Gene tetR
Product tetracycline resistance regulator protein
Function involved in resistance to tetracyclines
 
Gene tet(G)
Product tetracycline resistance protein
Function confers resistance to tetracyclines
 
Gene tnp
Product transposase
Function involved in transposition of DNA segments
 
Gene tns
Product transposition protein
Function involved in transposition of DNA segments
 

Y

Gene ybe
Product hypothetical protein
Function unknown
 
Gene ybf
Product hypothetical protein
Function unknown
 
Gene ybg
Product hypothetical protein
Function unknown