Nomenclature of Gene Cassettes
To avoid incorrect naming and the attribution of different names to identical gene cassettes,
INTEGRALL suggests the following nomenclature scheme.
Only integrons with new and completely sequenced gene cassette arrays should be considered for the attribution of new In numbers, according to the following scheme:
Check here the list of currently attributed In numbers (courtesy of Dr. Thomas Jové).
For new In attributions, please contact us.
In the case of aminoglycoside-resistant determinants, INTEGRALL suggests the nomenclature proposed by Novick et al. (1976).
Arabic numbers should be used to designate different subdivisions.
|
Family
|
Gene
|
Synonymous
|
Enzyme
|
|
Aminoglycoside Acetyltransferases
|
aacA
|
aac(6')
|
6'-N-acetyltransferase
|
|
aacB
|
aac(2')
|
2'-N-acetyltransferase
|
|
aacC
|
aac(3)
|
3-N-acetyltransferase
|
|
Aminoglycoside Adenyltransferases
|
aadA
|
ant(3'')
|
aminoglycoside-3''-adenylyltransferase
|
|
aadB
|
ant(2'')
|
aminoglycoside-2''-adenyltransferase
|
|
Aminoglycoside Phosphoryltransferases
|
aphA
|
aph(3')
|
aminoglycoside-3'-phosphotransferase
|
In the case of beta-lactamase encoding genes, the name of the enzyme (in capitals) should be preceded with bla (e.g. blaOXA-10).
Please check the standard beta-lactamase nomenclature at http://www.lahey.org/Studies/
In the case of trimethoprim-resistant determinants, INTEGRALL has adopted the nomenclature summarised by White and Rawlinson (2001).
Arabic numbers should also be used to designate different subdivisions.
|
Family
|
Gene
|
Synonymous
|
Enzyme
|
|
Dihydrofolate
Reductases
Type A
|
dfrA1
|
dfrI
|
DHFRI
|
|
dfrA5
|
dfrV
|
DHFRV
|
|
dfrA6
|
dfrVI
|
DHFRVI
|
|
dfrA7
|
dfrVII
|
DHFRVII
|
|
dfrA12
|
dfrXII
|
DHFRXII
|
|
dfrA13
|
dfrXIII
|
DHFRXIII
|
|
dfrA14
|
dfrXIVb
|
DHFRXIb
|
|
dfrA15
|
dfrXV
|
DHFRXV
|
|
dfrA15b
|
dfrXVb
|
DHFRVb
|
|
dfrA16
|
dfrXVI
|
DHFRVI
|
|
dfrA16b
|
dfrXVIb
|
DHFRVIb
|
|
dfrA17
|
dfrXVII
|
DHFRXVII
|
|
Dihydrofolate Reductases
Type B
|
dfrB1
|
dfrIIa
|
DHFRIIa
|
|
dfrB2
|
dfrIIb
|
DHFRIIb
|
|
dfrB3
|
dfrIIc
|
DHFRIIc
|
|
