INTEGRALL

The Integron Database

Klebsiella pneumoniae
Accession Number: CP025147
Source: blood - USA: New York City
Journal: Unpublished
Published: 12-DEC-2017
Title: Successive emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in blaKPC-2-harboring Klebsiella pneumoniae ST307
Authors: Giddins,M.J., Macesic,N., Annavajhala,M.K., Stump,S., Khan,S., McConville,T.H., Mehta,M., Gomez-Simmonds,A., Uhlemann,A.-C.
Remarks: Class 1 integron. In1252
Promoter: PcWTGN-10
Gene Product Sequence
(782..3)
AAA family ATPase (782..3)
(1804..779)
IS21 family transposase (1804..779)
(1889..2464)
restriction endonuclease subunit M (1889..2464)
(2789..2517)
hypothetical protein (2789..2517)
(4019..2838)
chromosome partitioning protein ParB (4019..2838)
(4808..4023)
ParA family protein (4808..4023)
(5293..4982)
hypothetical protein (5293..4982)
(5576..5499)
transcriptional regulator (5576..5499)
(5600..6415)
sulfonamide-resistant dihydropteroate synthase Sul2 (5600..6415)
(6502..6804)
phosphoglucosamine mutase (6502..6804)
(6949..6698)
hypothetical protein (6949..6698)
(7552..6980)
IS91-like element ISVsa3 family transposase (7552..6980)
(7893..7456)
DUF4102 domain-containing protein (7893..7456)
(8530..8099)
hypothetical protein (8530..8099)
(9791..8544)
site-specific DNA-methyltransferase (9791..8544)
(10143..9781)
hypothetical protein (10143..9781)
(10388..10146)
hypothetical protein (10388..10146)
(10639..10388)
hypothetical protein (10639..10388)
(10823..10626)
hypothetical protein (10823..10626)
(11761..10823)
chromosome partitioning protein ParB (11761..10823)
(12423..11878)
hypothetical protein (12423..11878)
(12995..12426)
hypothetical protein (12995..12426)
(13570..13007)
hypothetical protein (13570..13007)
(14004..13750)
transcriptional regulator (14004..13750)
(15213..14050)
hypothetical protein (15213..14050)
(15692..15213)
phage tail protein (15692..15213)
(18154..15707)
phage tail tape measure protein (18154..15707)
(18266..18147)
GpE family phage tail protein (18266..18147)
(18574..18299)
phage tail assembly protein (18574..18299)
(19149..18631)
phage major tail tube protein (19149..18631)
(20352..19162)
phage tail protein (20352..19162)
(21011..20412)
DNA-invertase (21011..20412)
(21036..21425)
hypothetical protein (21036..21425)
(21447..21887)
tail assembly chaperone (21447..21887)
(22461..21859)
tail fiber assembly protein (22461..21859)
(23795..22461)
phage tail protein (23795..22461)
(24403..23792)
phage tail protein I (24403..23792)
(25304..24396)
baseplate assembly protein (25304..24396)
(25656..25309)
baseplate assembly protein (25656..25309)
(26288..25653)
phage baseplate assembly protein V (26288..25653)
(26807..26355)
phage virion morphogenesis protein (26807..26355)
(27267..26800)
phage tail protein (27267..26800)
(27403..27230)
phage lysis protein (27403..27230)
(27800..27375)
protein lysB (27800..27375)
(28213..27788)
protein lysA (28213..27788)
(28725..28228)
lysozyme (28725..28228)
(29006..28725)
holin (29006..28725)
(29213..29010)
phage tail protein (29213..29010)
(29722..29213)
head completion/stabilization protein (29722..29213)
(30565..29822)
terminase (30565..29822)
(31642..30569)
phage major capsid protein, P2 family (31642..30569)
(32555..31701)
capsid scaffolding protein (32555..31701)
(32729..34501)
oxidoreductase (32729..34501)
(34501..35535)
phage portal protein (34501..35535)
(35930..37474)
hypothetical protein (35930..37474)
(37858..37640)
hypothetical protein (37858..37640)
(40238..37962)
replication endonuclease (40238..37962)
(40503..40228)
hypothetical protein (40503..40228)
(40724..40500)
hypothetical protein (40724..40500)
(41026..40727)
hypothetical protein (41026..40727)
(41250..41026)
DUF2732 domain-containing protein (41250..41026)
(41814..41314)
replication protein B (41814..41314)
(42267..41992)
hypothetical protein (42267..41992)
(42389..42688)
helix-turn-helix domain-containing protein (42389..42688)
(42804..43817)
site-specific integrase (42804..43817)
(44266..43880)
hypothetical protein (44266..43880)
(44610..44263)
hypothetical protein (44610..44263)
(45806..44622)
hypothetical protein (45806..44622)
(45994..45800)
hypothetical protein (45994..45800)
(46435..46043)
hypothetical protein (46435..46043)
(46769..46440)
hypothetical protein (46769..46440)
(48388..46925)
ATPase (48388..46925)
(49394..48462)
hypothetical protein (49394..48462)
(49852..49589)
hypothetical protein (49852..49589)
(50453..49956)
hypothetical protein (50453..49956)
(50917..50456)
DUF1643 domain-containing protein (50917..50456)
(51035..51376)
hypothetical protein (51035..51376)
(51861..51391)
hypothetical protein (51861..51391)
(52225..51854)
hypothetical protein (52225..51854)
(52430..52236)
hypothetical protein (52430..52236)
(52681..52430)
hypothetical protein (52681..52430)
(53319..52771)
transcriptional regulator (53319..52771)
(53482..53832)
diaminopimelate decarboxylase (53482..53832)
(53837..54139)
transcriptional regulator (53837..54139)
(54459..54166)
chromosome segregation protein ParM (54459..54166)
(54819..54547)
HU family DNA-binding protein (54819..54547)
(55353..54877)
nuclease (55353..54877)
(55352..55498)
ABC transporter (55352..55498)
(56526..55546)
IS5-like element ISKpn26 family transposase (56526..55546)
(56809..56621)
hypothetical protein (56809..56621)
(57692..56835)
hypothetical protein (57692..56835)
(57909..57679)
hypothetical protein (57909..57679)
(58427..57909)
nitrite reductase (58427..57909)
(58870..58424)
Fe3+-siderophore ABC transporter permease (58870..58424)
(59229..58870)
hypothetical protein (59229..58870)
(59714..59286)
hypothetical protein (59714..59286)
(60608..59748)
protein-disulfide isomerase (60608..59748)
(61601..60624)
S49 family peptidase (61601..60624)
(62437..61583)
hypothetical protein (62437..61583)
(62756..62442)
hypothetical protein (62756..62442)
(63189..62746)
hypothetical protein (63189..62746)
(63837..63316)
hypothetical protein (63837..63316)
(64301..63840)
hypothetical protein (64301..63840)
(64974..64366)
hypothetical protein (64974..64366)
(65243..66358)
phosphohydrolase (65243..66358)
(66376..66810)
hypothetical protein (66376..66810)
(67014..67199)
hypothetical protein (67014..67199)
(67501..67220)
hypothetical protein (67501..67220)
(68947..67847)
plasmid replication protein (68947..67847)
(69219..68932)
hypothetical protein (69219..68932)
(69790..69224)
hypothetical protein (69790..69224)
(70262..71245)
plasmid stability protein StbA (70262..71245)
(71262..71555)
hypothetical protein (71262..71555)
(71557..71976)
DNA-binding protein (71557..71976)
(72587..72036)
regulator (72587..72036)
(73192..72584)
transcriptional regulator (73192..72584)
(73736..73203)
transglycosylase (73736..73203)
(74008..73736)
nucleotide excision repair protein (74008..73736)
(74724..75086)
permease (74724..75086)
(78738..75124)
conjugal transfer protein TraG (78738..75124)
(78758..78856)
exopolygalacturonate lyase (78758..78856)
(79648..78866)
transposase (79648..78866)
(80667..79645)
IS21 family transposase (80667..79645)
(80788..80681)
glutathione S-transferase (80788..80681)
(82143..80734)
conjugal transfer protein TraH (82143..80734)
(83185..82145)
conjugal transfer protein TraF (83185..82145)
(84807..83296)
ATP-dependent helicase (84807..83296)
(85094..84816)
hypothetical protein (85094..84816)
(86134..85094)
KfrA protein (86134..85094)
(88066..86351)
integrase (88066..86351)
(88176..91205)
Tn3 family transposase (88176..91205)
(91312..92337)
IS21 family transposase (91312..92337)
(92334..93113)
AAA family ATPase (92334..93113)
(93247..94128)
carbapenem-hydrolyzing class A beta-lactamase KPC-2 (93247..94128)
(95697..94378)
IS1182-like element ISKpn6 family transposase (95697..94378)
(96920..96042)
DNA replication terminus site-binding protein (96920..96042)
(98586..97582)
IS110 family transposase (98586..97582)
merR (99099..98665)
merR mercuric resistance operon regulatory protein (99099..98665)
(99171..99521)
mercuric transporter (99171..99521)
merP (99535..99810)
merP mercuric transporter periplasmic component (99535..99810)
(99846..100268)
mercury transport protein MerC (99846..100268)
(100320..102014)
mercury(II) reductase (100320..102014)
merD (102032..102394)
merD mercuric resistance transcriptional repressor protein MerD (102032..102394)
(102391..102627)
mercury resistance protein (102391..102627)
(102624..103331)
EAL domain-containing protein (102624..103331)
(103438..103265)
resolvase (103438..103265)
(103370..105085)
transposase (103370..105085)
(105088..106080)
transposase (105088..106080)
(106548..106049)
GNAT family N-acetyltransferase (106548..106049)
(106567..106746)
hypothetical protein (106567..106746)
(107515..106676)
sulfonamide-resistant dihydropteroate synthase Sul1 (107515..106676)
qacE (107856..107509)
qacE quaternary ammonium compound efflux SMR transporter QacE delta 1 (107856..107509)
aac(6') (108638..108084)
aac(6') aminoglycoside 6'-N-acetyltransferase AAC(6')-33 (108638..108084)
aadB (109272..108739)
aadB aminoglycoside nucleotidyltransferase ANT(2'')-Ia (109272..108739)
(109418..110431)
integrase/recombinase (109418..110431)
(110376..110699)
transposase (110376..110699)
(110737..111294)
recombinase family protein (110737..111294)
(111297..114269)
Tn3 family transposase (111297..114269)
(114348..115352)
IS110 family transposase IS4321 (114348..115352)
(115794..116351)
recombinase (115794..116351)
blaTEM (116534..117394)
blaTEM class A broad-spectrum beta-lactamase TEM-1 (116534..117394)
(117403..117519)
adenine-specific DNA-methyltransferase (117403..117519)
(118169..117465)
IS6 family transposase IS15DIV (118169..117465)
(118569..118357)
DUF3330 domain-containing protein (118569..118357)
(118532..118651)
mercury resistance protein (118532..118651)
(118871..118635)
mercury resistance protein (118871..118635)
merD (119233..118868)
merD transcriptional regulator (119233..118868)
merA (120936..119251)
merA mercury(II) reductase (120936..119251)
(121400..120975)
mercury transport protein MerC (121400..120975)
merP (121703..121428)
merP mercuric transporter periplasmic component (121703..121428)
(122084..121719)
mercuric transport protein (122084..121719)
merR (122156..122611)
merR Hg(II)-responsive transcriptional regulator (122156..122611)
(123083..122601)
hypothetical protein (123083..122601)
(123949..123080)
3'-5' exonuclease (123949..123080)
(124964..123954)
integrase (124964..123954)
(125503..124967)
hypothetical protein (125503..124967)
(125783..125496)
hypothetical protein (125783..125496)
(126122..125802)
hypothetical protein (126122..125802)
(126345..126947)
hypothetical protein (126345..126947)
(127415..126963)
hypothetical protein (127415..126963)
(127917..127582)
hypothetical protein (127917..127582)
(128448..128176)
hypothetical protein (128448..128176)
(132707..128445)
type IV secretion protein Rhs (132707..128445)
(133565..132840)
hypothetical protein (133565..132840)
(134080..133679)
hypothetical protein (134080..133679)
(134539..134300)
permease (134539..134300)
(134890..134612)
hypothetical protein (134890..134612)
(136604..134877)
DNA primase (136604..134877)
(137168..136782)
hypothetical protein (137168..136782)
(138477..137626)
NgrC (138477..137626)
(139109..138552)
pyruvate dehydrogenase (139109..138552)
(139401..139183)
hypothetical protein (139401..139183)
(139684..139415)
hypothetical protein (139684..139415)
(140282..139677)
5'-deoxynucleotidase (140282..139677)
(140557..140354)
hypothetical protein (140557..140354)
(143212..140759)
phosphoadenosine phosphosulfate reductase (143212..140759)
(143686..143300)
hypothetical protein (143686..143300)
(144473..143919)
hypothetical protein (144473..143919)
(145023..144547)
hypothetical protein (145023..144547)
(146664..145039)
DNA cytosine methyltransferase (146664..145039)
(147044..146742)
hypothetical protein (147044..146742)
(147466..147122)
hypothetical protein (147466..147122)
(147721..148833)
IS4 family transposase (147721..148833)
(149385..149008)
topoisomerase II (149385..149008)
(149621..149430)
hypothetical protein (149621..149430)
(149978..149679)
hypothetical protein (149978..149679)
(150411..149959)
hypothetical protein (150411..149959)
(150790..150401)
hypothetical protein (150790..150401)
(151076..150852)
ferredoxin (151076..150852)
(151252..151142)
DNA adenine modification methylase (151252..151142)
(152102..151320)
transposase (152102..151320)
(153121..152099)
IS21 family transposase (153121..152099)
(153248..153135)
coproporphyrinogen III oxidase (153248..153135)
(154151..153336)
DNA adenine modification methylase (154151..153336)
(154686..154186)
hypothetical protein (154686..154186)
(155316..154777)
hypothetical protein (155316..154777)
(155916..155581)
hypothetical protein (155916..155581)
(157774..155978)
VWA domain-containing protein (157774..155978)
(159136..157859)
DUF3150 domain-containing protein (159136..157859)
(159218..159430)
hypothetical protein (159218..159430)
(160346..159336)
endonuclease (160346..159336)
bet (161398..160409)
bet phage recombination protein Bet (161398..160409)
(162023..161493)
single-stranded DNA-binding protein (162023..161493)
(162992..162084)
hypothetical protein (162992..162084)
(163971..163003)
CbbQ/NirQ/NorQ/GpvN family protein (163971..163003)
(164376..164191)
hypothetical protein (164376..164191)
(165000..164680)
hypothetical protein (165000..164680)
(165294..165935)
hypothetical protein (165294..165935)
(166058..166918)
hypothetical protein (166058..166918)
(169767..166957)
conjugal transfer protein TraN (169767..166957)
(170878..169871)
conjugal transfer protein TraU (170878..169871)
(171546..170875)
diguanylate phosphodiesterase (171546..170875)
(172808..171543)
conjugal transfer protein TraW (172808..171543)
(173301..172771)
S26 family signal peptidase (173301..172771)
(173615..173298)
hypothetical protein (173615..173298)
traC (176077..173630)
traC type IV secretion system protein TraC (176077..173630)
(176781..176074)
disulfide isomerase (176781..176074)
(182461..176930)
hypothetical protein (182461..176930)
(183054..182662)
conjugal transfer protein TraA (183054..182662)
traV (183636..183058)
traV type IV conjugative transfer system protein TraV (183636..183058)
(184949..183633)
conjugal transfer protein TraB (184949..183633)
(185863..184946)
conjugal transfer protein TraK (185863..184946)
(186473..185847)
pilus assembly protein (186473..185847)
traL (186751..186470)
traL type IV conjugative transfer system protein TraL (186751..186470)
(187273..186896)
hypothetical protein (187273..186896)
(188259..187597)
hypothetical protein (188259..187597)
(188636..188259)
hypothetical protein (188636..188259)
(189092..188646)
hypothetical protein (189092..188646)
(189731..189102)
DUF4400 domain-containing protein (189731..189102)
(190272..189688)
hypothetical protein (190272..189688)
(192148..190283)
conjugal transfer protein (192148..190283)
(195123..192145)
conjugal transfer protein TraI (195123..192145)
(195291..195908)
hypothetical protein (195291..195908)
(195890..196123)
hypothetical protein (195890..196123)
(196123..198315)
DNA topoisomerase III (196123..198315)
(198330..198818)
hypothetical protein (198330..198818)
(199209..198910)
RNA-binding protein (199209..198910)
(199420..199214)
hypothetical protein (199420..199214)
(200038..199421)
phage head-tail adapter protein (200038..199421)
(200350..200132)
hypothetical protein (200350..200132)
(201212..200556)
hypothetical protein (201212..200556)
(202639..201212)
DNA cytosine methyltransferase (202639..201212)
(203143..202643)
hypothetical protein (203143..202643)
(203484..203152)
hypothetical protein (203484..203152)
(203900..203469)
hypothetical protein (203900..203469)
(204642..203968)
thymidylate kinase (204642..203968)
(204898..204617)
hypothetical protein (204898..204617)
(205268..204891)
hypothetical protein (205268..204891)
(205822..205899)
restriction endonuclease subunit M (205822..205899)